About 2 results found for searched term "Pyridone 6" (0.122 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3737 | Pyridone 6 | JAK |
| Merck-5, CMP 6, JAK Inhibitor I | ||
| Pyridone 6 is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1 (IC50 = 15 nM for murine JAK1), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk 2 (IC50 = 1 nM) (Janus protein tyrosine kinases). | ||
| M28689 | NITD-916 | Antibiotic |
| NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active and highly lipophilic mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 has potent anti-tuberculosis effects. | ||
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